Disentangling Genetic Variation for Resistance and Tolerance to Infectious Diseases in Animals
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چکیده
منابع مشابه
Disentangling genetic variation for resistance and tolerance to infectious diseases in animals.
Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in lab...
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Despite traditional disease control measures, losses attributable to infectious diseases continue to impede the livestock industries. An alternative approach to this problem is genetic disease resistance involving both immune and non-immune mechanisms, which is the inherent capacity of a previously unexposed animal to resist disease when challenged by pathogens. Although the nurturing environme...
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This paper reviews the evidence for host genetic variation in resistance to infectious diseases for a wide variety of diseases of economic importance in poultry, cattle, pig, sheep and Atlantic salmon. Further, it develops a method of ranking each disease in terms of its overall impact, and combines this ranking with published evidence for host genetic variation and information on the current s...
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ژورنال
عنوان ژورنال: Science
سال: 2007
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1148526